Basal Patologi KU - BAD, BID and PUMA proteins shift the balance between the pro-apoptotic and anti-apoptotic family members by neutralizing the actions of anti-apoptotic proteins like BCL2 and BCL-XL, thereby promoting
Phylogenetically Distant Viruses Use the Same BH3-Only Protein Puma to Trigger Bax/Bak-Dependent Apoptosis of Infected Mouse and Human Cells | PLOS ONE
![How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? | Cell Death & Differentiation How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? | Cell Death & Differentiation](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fcdd.2017.169/MediaObjects/41418_2018_Article_BFcdd2017169_Fig1_HTML.jpg)
How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? | Cell Death & Differentiation
BH3-only sensors Bad, Noxa and Puma are Key Regulators of Tacaribe virus-induced Apoptosis | PLOS Pathogens
![6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death | Molecular Neurodegeneration | Full Text 6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death | Molecular Neurodegeneration | Full Text](https://media.springernature.com/full/springer-static/image/art%3A10.1186%2F1750-1326-6-2/MediaObjects/13024_2010_Article_158_Fig9_HTML.jpg)
6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death | Molecular Neurodegeneration | Full Text
![Frontiers | Platycodin D induces apoptosis through JNK1/AP-1/PUMA pathway in non-small cell lung cancer cells: A new mechanism for an old compound Frontiers | Platycodin D induces apoptosis through JNK1/AP-1/PUMA pathway in non-small cell lung cancer cells: A new mechanism for an old compound](https://www.frontiersin.org/files/Articles/1045375/fphar-13-1045375-HTML/image_m/fphar-13-1045375-g007.jpg)
Frontiers | Platycodin D induces apoptosis through JNK1/AP-1/PUMA pathway in non-small cell lung cancer cells: A new mechanism for an old compound
![WRN suppresses p53/PUMA-induced apoptosis in colorectal cancer with microsatellite instability/mismatch repair deficiency | PNAS WRN suppresses p53/PUMA-induced apoptosis in colorectal cancer with microsatellite instability/mismatch repair deficiency | PNAS](https://www.pnas.org/cms/10.1073/pnas.2219963120/asset/379249bb-a5ef-437c-950f-999085227123/assets/images/large/pnas.2219963120fig01.jpg)
WRN suppresses p53/PUMA-induced apoptosis in colorectal cancer with microsatellite instability/mismatch repair deficiency | PNAS
![Inhibiting aberrant p53-PUMA feedback loop activation attenuates ischaemia reperfusion-induced neuroapoptosis and neuroinflammation in rats by downregulating caspase 3 and the NF-κB cytokine pathway | Journal of Neuroinflammation | Full Text Inhibiting aberrant p53-PUMA feedback loop activation attenuates ischaemia reperfusion-induced neuroapoptosis and neuroinflammation in rats by downregulating caspase 3 and the NF-κB cytokine pathway | Journal of Neuroinflammation | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs12974-018-1271-9/MediaObjects/12974_2018_1271_Fig2_HTML.png)
Inhibiting aberrant p53-PUMA feedback loop activation attenuates ischaemia reperfusion-induced neuroapoptosis and neuroinflammation in rats by downregulating caspase 3 and the NF-κB cytokine pathway | Journal of Neuroinflammation | Full Text
![ART increases PUMA protein level. PANC-1 (A), BxPC-3 (B), and HCT116... | Download Scientific Diagram ART increases PUMA protein level. PANC-1 (A), BxPC-3 (B), and HCT116... | Download Scientific Diagram](https://www.researchgate.net/publication/321702205/figure/fig5/AS:569629856759813@1512821749535/ART-increases-PUMA-protein-level-PANC-1-A-BxPC-3-B-and-HCT116-C-cells-were.png)
ART increases PUMA protein level. PANC-1 (A), BxPC-3 (B), and HCT116... | Download Scientific Diagram
![Multimodal Interaction with BCL-2 Family Proteins Underlies the Proapoptotic Activity of PUMA BH3 - ScienceDirect Multimodal Interaction with BCL-2 Family Proteins Underlies the Proapoptotic Activity of PUMA BH3 - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S1074552113002408-fx1.jpg)